Search results for "Perypheral cytokine"

FROM THE BLOOD- BRAIN BARRIER TO BEHAVIOR

2017

Research in the field of neuropsychoimmunology has enabled the researchers to show that cytokines target the brain to organize a "sickness response," which is fever, activation of hypothalamuspituitary- adrenal axis and behavioural alterations that develop in sick individuals. perypheral cytokines do not act directly on the brain; they trigger the production of cytokines in the brain parenchima itself, with a possible relay at the interface between internal milieeu and the brain, which are endothelial cells and circumven- tricular organs. The affective and behavioural changes that develop during in- fluenza are the product of a transient brain inflammatory response induced by the same proin…